Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.

@article{Shin2003Interleukin1H,
  title={Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.},
  author={Hyoung Doo Shin and Byung Park and Lyoung Hyo Kim and Ji Hyun Jung and Jun Yeon Kim and Jung Hwan Yoon and Yoon Jun Kim and Hyo-suk Lee},
  journal={Human molecular genetics},
  year={2003},
  volume={12 8},
  pages={901-6}
}
Interleukin 10 (IL10) is a powerful Th-2 cell cytokine produced by lymphoid cells that exerts its functions by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFA, TGFB, IL6, IL8 and IL12). Genetic association analysis of a well-characterized HBV cohort revealed that one of IL10 haplotypes, IL10-ht2, was strongly associated with hepatocellular carcinoma (HCC) occurrence in gene dose-dependent manner. The frequency of susceptible… CONTINUE READING