Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma.

@article{Karjalainen2003Interleukin10GP,
  title={Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma.},
  author={Jussi Karjalainen and Janne Hulkkonen and Markku M. Nieminen and Heini Sisko Annamari Huhtala and Arpo R J Aromaa and Timo Klaukka and Mikko A. Hurme},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2003},
  volume={33 1},
  pages={78-83}
}
BACKGROUND IL-10 has several functional effects relevant to asthma. It can modulate IgE production and induce apoptosis in eosinophils. Polymorphisms of IL-10 gene have been shown to affect IL-10 production. OBJECTIVE To establish whether IL-10 polymorphisms are associated with asthma and phenotype-related characteristics. METHODS The frequency of three single base exchange polymorphisms (at positions - 1082, - 819 and - 592) and corresponding haplotypes of the IL-10 gene were analysed in… CONTINUE READING

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