Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.

@article{Ito2007Interleukin10EM,
  title={Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.},
  author={Takayuki Ito and Takashi Okada and Hiroshi Miyashita and Tatsuya Nomoto and Mutsuko Nonaka-Sarukawa and Ryosuke Uchibori and Yoshikazu Maeda and Masashi Urabe and Hiroaki Mizukami and Akihiro Kume and Masafumi Takahashi and Uichi Ikeda and Kazuyuki Shimada and Keiya Ozawa},
  journal={Circulation research},
  year={2007},
  volume={101 7},
  pages={
          734-41
        }
}
Pulmonary arterial hypertension (PAH) is a fatal disease associated with inflammation and pathological remodeling of the pulmonary artery (PA). Interleukin (IL)-10 is a pleiotropic antiinflammatory cytokine with vasculoprotective properties. Here, we report the preventive effects of IL-10 on monocrotaline-induced PAH. Three-week-old Wistar rats were intramuscularly injected with an adeno-associated virus serotype 1 vector expressing IL-10, followed by monocrotaline injection at 7 weeks old. IL… CONTINUE READING
Highly Cited
This paper has 59 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 44 citations

59 Citations

0510'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 59 citations based on the available data.

See our FAQ for additional information.