Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients.

@article{Lauwerys2000Interleukin10BC,
  title={Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients.},
  author={Bernard R Lauwerys and Nathalie Garot and Jean-Christophe Renauld and Fr{\'e}d{\'e}ric A. Houssiau},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 9},
  pages={1976-81}
}
OBJECTIVE Many systemic lupus erythematosus (SLE) patients display impaired cellular immune responses against allo- or recall antigens. Given the down-regulating properties of interleukin-10 (IL-10) on antigen-presenting cell functions, this study was undertaken to investigate whether the well-known overproduction of IL-10 by SLE peripheral blood mononuclear cells (PBMC) was involved in this process. METHODS We measured the proliferation of SLE or control PBMC against irradiated allogeneic… CONTINUE READING

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