Interleukin-10 attenuates experimental fetal growth restriction and demise.

  title={Interleukin-10 attenuates experimental fetal growth restriction and demise.},
  author={Dana L. Rivera and Staci M. Olister and Xu-hui Liu and Jane H Thompson and Xian Jun Zhang and K. J. Pennline and Ricardo Azuero and David A. Clark and Mark J Miller},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={12 2},
Premature labor, fetal demise, and fetal growth restriction are accompanied by indices of inflammation or infection of the uteroplacental unit. To understand whether these events are causally related, we established an animal model of fetal demise and growth restriction and evaluated the potential utility of the anti-inflammatory cytokine interleukin-10 (IL-10). We administered low-dose endotoxin (lipopolysaccharide, or LPS, 100 microg/kg, i.p.) to third trimester rats (gestational days 14-20… CONTINUE READING
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