Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier.

@article{Kastin2003Interleukin10AA,
  title={Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier.},
  author={AbbaJ. Kastin and Victoria L Akerstrom and Weihong Pan},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={114 2},
  pages={
          168-71
        }
}
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that 125I-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted. 
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