Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

@article{Murai2009Interleukin1A,
  title={Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis},
  author={Masako Murai and O. V. Turovskaya and Gun Woo Kim and Rashna Madan and Christopher L. Karp and Hilde Cheroutre and Mitchell Kronenberg},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={1178-1184}
}
Regulatory T cells (Treg cells) that express the transcription factor Foxp3 suppress the activity of other cells. Here we show that interleukin 10 (IL-10) produced by CD11b+ myeloid cells in recombination-activating gene 1–deficient (Rag1−/−) recipient mice was needed to prevent the colitis induced by transferred CD4+CD45RBhi T cells. In Il10−/−Rag1−/− mice, Treg cells failed to maintain Foxp3 expression and regulatory activity. The loss of Foxp3 expression occurred only in recipients with… CONTINUE READING
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