Interleukin-10 ablation promotes tumor development, growth, and metastasis.

  title={Interleukin-10 ablation promotes tumor development, growth, and metastasis.},
  author={Takashi Tanikawa and Cailin Moira Wilke and Ilona Kryczek and Grace Y Chen and John Kao and Gabriel N{\'u}{\~n}ez and Weiping Zou},
  journal={Cancer research},
  volume={72 2},
Interleukin-10 (IL-10) is a broadly acting immune inhibitory cytokine that is generally thought to support tumor growth. Here we challenge this view with evidence that genetic ablation of IL-10 in the mouse significantly heightens sensitivity to chemical carcinogenesis, growth of transplanted tumors, and formation of metastases. Tumor growth in IL-10-deficient (IL-10(-/-)) mice was associated with an increased level of myeloid-derived suppressor cells (MDSC) and CD4(+)Foxp3(+) regulatory T… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 58 extracted citations


Publications referenced by this paper.
Showing 1-10 of 47 references

Proinflammatory effects of IL-10 during human endotoxemia

  • LauwFN, D Pajkrt, HackCE, KurimotoM, SJ vanDeventer, T vanderPoll
  • J Immunol
  • 2000
Highly Influential
4 Excerpts

Response: endogenous IL-17, tumor growth, and metastasis

  • S Wei, I Kryczek, J Namm, W Szeliga, L Vatan, AE Chang
  • Blood
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…