Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

@inproceedings{Schottelius1999Interleukin10SB,
  title={Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding},
  author={Arndt J.G. Schottelius and Marty W. Mayo and Ryan Balfour Sartor and Albert S Baldwin},
  year={1999}
}
Abstract The transcription factor nuclear factor κB (NF-κB) coordinates the activation of numerous genes in response to pathogens and proinflammatory cytokines and is, therefore, pivotal in the development of acute and chronic inflammatory diseases. In its inactive state, NF-κB is constitutively present in the cytoplasm as a p50-p65 heterodimer bound to its inhibitory protein IκB. Proinflammatory cytokines, such as tumor necrosis factor (TNF), activate NF-κB by stimulating the activity of the I… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS, ESTIMATED 47% COVERAGE

Anti-inflammatory defense mechanisms of Entamoeba histolytica

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2000
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations