Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease.

@article{Colombel2001Interleukin1,
  title={Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease.},
  author={Jean Fr{\'e}d{\'e}ric Colombel and Paul Rutgeerts and Howard L. Malchow and Marianna Jacyna and O H Nielsen and J{\o}rgen Rask-Madsen and Sander J.H. van Deventer and Anne Ferguson and Pierre Desreumaux and Alastair Forbes and Karel Geboes and Lorenzo Melani and Marielle Cohard},
  journal={Gut},
  year={2001},
  volume={49 1},
  pages={
          42-6
        }
}
BACKGROUND AND AIMS New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety and tolerance of recombinant human interleukin 10 (IL-10; Tenovil) in subjects operated on for Crohn's disease. We also assessed the effect of Tenovil in preventing endoscopic recurrence 12 weeks after surgery. METHODS Patients with Crohn's disease who underwent curative ileal or ileocolonic… CONTINUE READING

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