Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study.

@article{Eder2007Interleukin10P,
  title={Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study.},
  author={Tanja Eder and Ramona Mayer and Uwe Langsenlehner and Wilfried Renner and Peter Krippl and Thomas C. Wascher and Karl Pummer and Karin Sigrid Kapp},
  journal={European journal of cancer},
  year={2007},
  volume={43 3},
  pages={472-5}
}
Interleukin-10 (IL-10) is a multifunctional cytokine acting as inhibitor of inflammatory and immune responses as well as tumour induced angiogenesis. A common [ATA] haplotype formed by polymorphisms at positions -1082, -819 and -592in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C>A polymorphism. To analyse the role of the IL-10 [ATA] haplotype in prostate cancer we performed a case-control… CONTINUE READING