Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes

@article{Fluckiger1993Interleukin1,
  title={Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes},
  author={A C Fluckiger and Pierre Garrone and Isabelle H. Durand and Jean Pierre Galizzi and Jacques Banchereau},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={1473 - 1481}
}
Interleukin 10 (IL-10) has recently been shown to induce normal human B lymphocytes to proliferate and differentiate into immunoglobulin (Ig)-secreting cells. Herein, we show that IL-10 also promotes DNA synthesis and IgM production by anti-CD40 activated B cell chronic lymphocytic leukemia (B-CLL). Most strikingly, IL-2 and IL-10 were found to synergize to induce the proliferation and differentiation of B-CLL cells. This synergy between IL-2 and IL-10 was also observed with normal B cells… CONTINUE READING
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