Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1.

@article{Maroso2011Interleukin1T1,
  title={Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1.},
  author={Mattia Maroso and Silvia Balosso and Teresa Ravizza and Jaron Zhongliang Liu and Marco Emilio Bianchi and Annamaria Vezzani},
  journal={Journal of internal medicine},
  year={2011},
  volume={270 4},
  pages={
          319-26
        }
}
Inflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti-inflammatory therapies both in clinical and in experimental settings, highlights the important role of brain inflammation in the aetiopathogenesis of seizures. Preclinical investigations in experimental models using pharmacological and genetic tools have identified a significant contribution of… CONTINUE READING
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