Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

@article{Goldring1988Interleukin1S,
  title={Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.},
  author={Mary B Goldring and James R Birkhead and Linda J. Sandell and Tomoatsu Kimura and Stephen M. Krane},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 6},
  pages={2026-37}
}
In inflammatory diseases such as rheumatoid arthritis, functions of chondrocytes including synthesis of matrix proteins and proteinases are altered through interactions with cells of the infiltrating pannus. One of the major secreted products of mononuclear inflammatory cells is IL-1. In this study we found that recombinant human IL-1 beta suppressed synthesis of cartilage-specific type II collagen by cultured human costal chondrocytes associated with decreased steady state levels of alpha 1… CONTINUE READING