Interleukin 1 stimulation of collagenase production by cultured fibroblasts

  title={Interleukin 1 stimulation of collagenase production by cultured fibroblasts},
  author={Arnold E. Postlethwaite and Lawrence B. Lachman and Carlo L. Mainardi and Andrew Kang},
  journal={The Journal of Experimental Medicine},
  pages={801 - 806}
Interleukin 1 is a monokine that exerts biological effects on a variety of target cells in vitro. In this report, interleukin 1 has been found to be capable of stimulating collagenase production by cultured dermal fibroblasts. The concentrations of interleukin 1 that stimulate fibroblast collagenase production are similar to those that stimulate mouse thymocyte proliferation. Analyses by high performance liquid chromatography indicate that interleukin 1, rather than a contaminating monokine, is… CONTINUE READING

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