Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release.

@article{Delwel1989Interleukin1SP,
  title={Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release.},
  author={Ruud Delwel and C van Buitenen and M Salem and Freek J Bot and Steven Gillis and Kenneth Kaushansky and Bruce W Altrock and Bob L{\"o}wenberg},
  journal={Blood},
  year={1989},
  volume={74 2},
  pages={586-93}
}
In this study, we further established the role of interleukin-1 (IL-1) alpha and IL-1 beta as regulators of proliferation of acute myeloid leukemia (AML) cells. IL-1 stimulated tritiated thymidine (3H-TdR) uptake of AML cells in 13 of 28 cases. Cytogenetic analysis confirmed the leukemic clonality of the IL-1-stimulated cells. Most likely, IL-1 exerted these stimulative effects directly on AML blast cells because IL-1 effectively induced 3H-TdR uptake of CD34-positive AML blasts (separated… CONTINUE READING