Interleukin-1 stimulates de novo synthesis of mitogen-activated protein kinase in glomerular mesangial cells.

@article{Huwiler1994Interleukin1SD,
  title={Interleukin-1 stimulates de novo synthesis of mitogen-activated protein kinase in glomerular mesangial cells.},
  author={Andrea Huwiler and Josef Martin Pfeilschifter},
  journal={FEBS letters},
  year={1994},
  volume={350 1},
  pages={135-8}
}
Interleukin-1 (IL-1) stimulates a time- and concentration-dependent mitogen-activated protein (MAP) kinase activation in rat mesangial cells. A rapid increase in activity (maximal at 10 min) is followed by a second persistent level of activity which steadily increases over 24 h. The second peak of MAP kinase activity is paralleled by a marked de novo synthesis of p42 MAP kinase as measured by immunoprecipitation of [35S]methionine-labelled mesangial cells and by a 60% increase in total p42 MAP… CONTINUE READING