Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.

@article{Paugh2009Interleukin1RT,
  title={Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.},
  author={Barbara S Paugh and Lauren Bryan and Steven W Paugh and Katarzyna M Wilczynska and Silvina M. Alvarez and Sandeep K. Singh and Dmitri Kapitonov and Hanna Rokita and Sarah Wright and Irene Griswold-Prenner and Sheldon Milstien and Sarah Spiegel and Tomasz Kordula},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 6},
  pages={3408-17}
}
Chronic inflammation and inflammatory cytokines have recently been implicated in the development and progression of various types of cancer. In the brain, neuroinflammatory cytokines affect the growth and differentiation of both normal and malignant glial cells, with interleukin 1 (IL-1) shown to be secreted by the majority of glioblastoma cells. Recently, elevated levels of sphingosine kinase 1 (SphK1), but not SphK2, were correlated with a shorter survival prognosis for patients with… CONTINUE READING

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