Interleukin-1 receptor antagonist originating from bone marrowderived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury.

@article{Isoda2014Interleukin1RA,
  title={Interleukin-1 receptor antagonist originating from bone marrowderived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury.},
  author={Kikuo Isoda and Koji Akita and Sarasa Isobe and Tomiharu Niida and Takeshi Adachi and Yoichiro Iwakura and Hiroyuki Daida},
  journal={Journal of atherosclerosis and thrombosis},
  year={2014},
  volume={21 11},
  pages={1208-18}
}
AIM Interleukin-1 receptor antagonist (IL-1Ra) negatively regulates IL-1 signaling by blocking the functional receptor. We previously demonstrated that IL-1Ra-deficient (IL-1Ra-/-) mice exhibit marked neointimal formation after injury. IL-1Ra is expressed on bone marrow (BM)-derived cells as well as non-BM intrinsic arterial cells. However, the importance of various cell types as sources of IL-1Ra remains unknown. The aim of this study was to test the hypothesis that IL-1Ra originating from BM… CONTINUE READING