Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

@article{Relton1992Interleukin1RA,
  title={Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat},
  author={J. Relton and N. Rothwell},
  journal={Brain Research Bulletin},
  year={1992},
  volume={29},
  pages={243-246}
}
Interleukin-1 (IL-1) synthesis in the brain is stimulated by mechanical injury and IL-1 mimics some effects of injury, such as gliosis and neovascularization. We report that neuronal death resulting from focal cerebral ischaemia (middle cerebral artery occlusion, 24 h) is significantly inhibited (by 50%) in rats injected with a recombinant IL-1 receptor antagonist (IL-1ra, 10 micrograms, icv 30 min before and 10 min after ischaemia). Excitotoxic damage due to striatal infusion of an NMDA… Expand
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