Interleukin-1 receptor antagonist in the fetomaternal compartment.

  title={Interleukin-1 receptor antagonist in the fetomaternal compartment.},
  author={Krisiina Bry and Kari Teramo and Urpo Lappalainen and Feizal Waffarn and Mikko K. Hallman},
  journal={Acta paediatrica},
  volume={84 3},
Interleukin-1 (IL-1) is a major mediator in infections and inflammation. Interleukin-1 receptor antagonist (IL-1ra) opposes the actions of IL-1. IL-1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL-1ra in amniotic fluid, fetal serum and newborn urine. The concentrations of IL-1ra in amniotic fluid at mid-trimester and at 25-41 gestational weeks were 6.6 +/- 0.5 ng/ml (n = 30) and 100 +/- 4 ng/ml (n = 202), respectively. At mid-trimester… CONTINUE READING
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