Interleukin-1 receptor antagonist gene polymorphism and multifetal pregnancy outcome.

  title={Interleukin-1 receptor antagonist gene polymorphism and multifetal pregnancy outcome.},
  author={Robin B. Kalish and Santosh Vardhana and Meruka Gupta and Stephen T. Chasen and Sriram C. Perni and Steven S Witkin},
  journal={American journal of obstetrics and gynecology},
  volume={189 4},
OBJECTIVE The purpose of this study was to determine whether interleukin-1 receptor antagonist and/or interleukin-1beta gene polymorphisms influence multifetal pregnancy outcome. STUDY DESIGN Maternal and neonatal buccal swabs from 51 multifetal gestations were analyzed for interleukin-1 receptor antagonist and interleukin-1beta alleles. Outcome data were obtained subsequently. RESULTS Fetal carriage of interleukin-1 receptor antagonist allele 1 was more than twice as prevalent as the… CONTINUE READING


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