Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.

@article{Fischer1992Interleukin1RA,
  title={Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.},
  author={Elena Fischer and Kimberly J Van Zee and Michael A. Marano and C S Rock and J Stanley Kenney and D D Poutsiaka and Charles A Dinarello and Stephen F. Lowry and Lyle L. Moldawer},
  journal={Blood},
  year={1992},
  volume={79 9},
  pages={2196-200}
}
Interleukin-1 receptor antagonist (IL-1ra) is a 22-Kd protein that shares homology with IL-1 beta, binds to the IL-1 receptor, but has no known agonist properties. This inhibitor appears to be the first cytokine whose sole function is to block the actions of another cytokine. Exogenous IL-1ra administration has been shown to reduce mortality in experimental septic shock. We now report that IL-1ra is endogenously produced and circulates in experimental inflammation and in clinical disease. After… CONTINUE READING