Interleukin-1 receptor antagonist attenuates leukocyte-endothelial interactions in the liver after hemorrhagic shock in the rat.

@article{Bauer1995Interleukin1RA,
  title={Interleukin-1 receptor antagonist attenuates leukocyte-endothelial interactions in the liver after hemorrhagic shock in the rat.},
  author={Clemens Bauer and Ingo Marzi and Michael Bauer and H Fellger and Reinhard Larsen},
  journal={Critical care medicine},
  year={1995},
  volume={23 6},
  pages={1099-105}
}
OBJECTIVE To evaluate the influence of interleukin-1 on leukocyte-endothelial cell interactions and the microcirculation in the liver after hemorrhagic shock by means of intravital microscopy using an interleukin-1 receptor antagonist (IL-1ra). DESIGN Prospective, randomized, blinded, controlled study. SETTING University research laboratory. SUBJECTS Anesthetized female Sprague Dawley rats weighing 200 to 230 g. INTERVENTIONS Hypovolemic shock was induced and maintained for 1 hr (mean… CONTINUE READING

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