Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder

@article{Hope2013Interleukin1R,
  title={Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder},
  author={Sigrun Hope and Thor Ueland and Nils Eiel Steen and I Dieset and Steinar Lorentzen and Akiah Ottesen Berg and Ingrid Agartz and P. A. Aukrust and Ole Andreas Andreassen},
  journal={Schizophrenia Research},
  year={2013},
  volume={145},
  pages={36-42}
}
BACKGROUND Previous studies suggest elevated inflammation in schizophrenia and bipolar disorder, with increased activity of the Interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor (TNF)-alpha, von Willebrand factor (vWf) and osteoprotegerin (OPG). It is unclear how immune activation is involved in the psychopathology. We investigated if elevated inflammation was associated with disease severity (trait) or current symptom level (state), comparing psychotic with general… CONTINUE READING
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