Interleukin-1 receptor antagonist (IL-1ra) production by human amnion, chorion, and decidua.

  title={Interleukin-1 receptor antagonist (IL-1ra) production by human amnion, chorion, and decidua.},
  author={Paul L. Fidel and Roberto Romero and Miguel de J. Ram{\'i}rez and Jason Cutright and Samuel S. Edwin and S Lamarche and David B. Cotton and Murray David Mitchell},
  journal={American journal of reproductive immunology},
  volume={32 1},
PROBLEM This study was conducted to determine whether (1) conditioned media from unstimulated primary cultures of human amnion, chorion, or decidua contain detectable concentrations of IL-1ra in vitro, and (2) bacterial endotoxin (LPS), tumor necrosis factor-alpha (TNF-alpha), or IL-1-beta (IL-1 beta) stimulate amnion, chorion, or decidua to produce increased amounts of IL-1ra. METHOD Placentae were obtained from women at term with intact membranes before the onset of labor. Amnion, chorion… CONTINUE READING


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