Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1B gene polymorphisms in Turkish patients with rheumatoid arthritis.

@article{Arman2006Interleukin1RA,
  title={Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1B gene polymorphisms in Turkish patients with rheumatoid arthritis.},
  author={Ahmet Arman and Bariş Yilmaz and A. Coker and Nevsun Inanç and Haner Direskeneli},
  journal={Clinical and experimental rheumatology},
  year={2006},
  volume={24 6},
  pages={643-8}
}
OBJECTIVE Interleukin 1 (IL-1) family is composed of two agonists, IL-1alpha and IL-1Beta and IL-1 receptor antagonist, IL-1Ra. The purpose of this study was to determine the relationship between polymorphisms of IL-1 receptor antagonist (IL-1RN), IL-1B promoter and IL-1B exon 5 genes and susceptibility to rheumatoid arthritis (RA) in Turkish population. METHODS Polymerase chain reaction (PCR) was used to determine the genotype of the IL-1RN for 94 RA patients and 104 healthy controls… CONTINUE READING

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