Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor.

@article{Malinowsky1998Interleukin1RA,
  title={Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor.},
  author={D Malinowsky and Johan Lundkvist and Sophie Lay{\'e} and Tamas Bartfai},
  journal={FEBS letters},
  year={1998},
  volume={429 3},
  pages={299-302}
}
Stably transfected HEK-293 cells express on their surface the murine type II IL-1 receptor (mIL-1RII) as demonstrated by FACS analysis using the mAb 4E2, however binding of [125I]-hrIL-1beta to these cells is nearly absent. Saturable high affinity binding of [125I]-hrIL-1beta is observed when the murine IL-1 receptor accessory protein (mIL-1RAcP) is coexpressed with mIL-1RII. Binding of [125I]-hrIL-1beta to mIL-1RII-mIL-1RAcP complex can be inhibited either with antibodies to mIL-1RII (mAb 4E2… CONTINUE READING

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