Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.

@article{Narayanan2008Interleukin1RM,
  title={Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.},
  author={Srihari Narayanan and Rosa Mar{\'i}a Corrales and William Johnson Farley and Alison Marie McDermott and Stephen Carl Pflugfelder},
  journal={Cornea},
  year={2008},
  volume={27 7},
  pages={811-7}
}
PURPOSE To compare inflammatory cytokine and defensin expression in response to experimental dry eye (EDE) in interleukin-1 receptor-1 (IL-1R1)-deficient (KO) mice with age-matched wild-type mice (WT). METHODS EDE was induced by subcutaneous scopolamine injection, exposure to low humidity, and an air draft for 5 days in 4- to 6-week-old KO and WT mice. Expression of cytokines IL-1 alpha, IL-1 beta, tumor necrosis factor (TNF)-alpha, IL-6, and mouse beta-defensins (mBD)-1, mBD-2, and mBD-3 was… CONTINUE READING
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