Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.

@article{Beaulieu2014Interleukin1R,
  title={Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.},
  author={Lea M. Beaulieu and Elaine Lin and Eric O. Mick and Milka Koupenova and Ellen O. Weinberg and Carolyn D. Kramer and Caroline Attardo Genco and Kahraman Tanriverdi and Martin G. Larson and Emelia J Benjamin and Jane E. Freedman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 3},
  pages={
          552-64
        }
}
OBJECTIVE Interleukin 1 Receptor 1 (IL1R1) and its ligand, IL1β, are upregulated in cardiovascular disease, obesity, and infection. Previously, we reported a higher level of IL1R1 transcripts in platelets from obese individuals of the Framingham Heart Study (FHS), but its functional effect in platelets has never been described. Additionally, IL1β levels are increased in atherosclerotic plaques and in bacterial infections. The aim of this work is to determine whether IL1β, through IL1R1, can… CONTINUE READING

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