Interleukin-1 potentiates the development of collagen-induced arthritis in mice.

@article{Killar1989Interleukin1PT,
  title={Interleukin-1 potentiates the development of collagen-induced arthritis in mice.},
  author={Loran M Killar and Colin J. Dunn},
  journal={Clinical science},
  year={1989},
  volume={76 5},
  pages={535-8}
}
1. The subcutaneous administration of recombinant human interleukin-1 beta (rhIL-1 beta) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1 beta had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1 beta may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for… CONTINUE READING

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