Interleukin-1 participates in the progression from liver injury to fibrosis.

@article{Gieling2009Interleukin1PI,
  title={Interleukin-1 participates in the progression from liver injury to fibrosis.},
  author={Roben G Gieling and Karen E. Wallace and Y P Han},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 6},
  pages={
          G1324-31
        }
}
Interleukin-1 (IL-1) is rapidly expressed in response to tissue damage; however, its role in coordinating the progression from injury to fibrogenesis is not fully understood. Liver fibrosis is a consequence of the activation of hepatic stellate cells (HSCs), which reside within the extracellular matrix (ECM) of subsinusoids. We have hypothesized that, among the hepatic inflammatory cytokines, IL-1 may directly activate HSCs through autocrine signaling and stimulate the matrix metalloproteinases… CONTINUE READING
Highly Cited
This paper has 144 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.

American journal of physiology. Gastrointestinal and liver physiology • 2018
View 3 Excerpts
Highly Influenced

Conjunctival transcriptome in scarring trachoma.

Infection and immunity • 2011
View 9 Excerpts
Highly Influenced

145 Citations

01020'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 145 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.

Liver international : official journal of the International Association for the Study of the Liver • 2008
View 3 Excerpts
Highly Influenced

Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2006
View 2 Excerpts