Interleukin-1-mediated stimulation of prostaglandin E production is without effect on plasminogen activator activity in human granulosa lutein cell cultures.

@article{Hurwitz1995Interleukin1mediatedSO,
  title={Interleukin-1-mediated stimulation of prostaglandin E production is without effect on plasminogen activator activity in human granulosa lutein cell cultures.},
  author={A. Hurwitz and Yuval Lavy and Zvesdana Finci-Yeheskel and Ariel Milwidsky and Shlomo Shimonovitz and Simcha Yagel and Eli Y Adashi and Neri Laufer and Mirza Mayer},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 10},
  pages={3018-24}
}
In continuation of earlier observations on the involvement of interleukin-1 (IL-1) in ovarian function, we examined the ability of IL-1 to modulate plasminogen activator (PA) activity and prostaglandin (PG) synthesis in human granulosa lutein cells (GLCs). Toward this goal, GLCs were obtained from women undergoing in vitro fertilization, preincubated with 10% fetal calf serum for 48 h, and subsequently cultured for 48 h in serum-free media in the absence or presence of IL-1 beta (10 ng/mL… CONTINUE READING