Interleukin 1 is an autocrine regulator of human endothelial cell growth.

  title={Interleukin 1 is an autocrine regulator of human endothelial cell growth.},
  author={Federico Cozzolino and Maria Gabriella Torcia and Donatella Aldinucci and Marina Ziche and Fabio Almerigogna and Daniele Bani and David M. Stern},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 17},
Proliferation of endothelial cells is regulated through the autocrine production of growth factors and the expression of cognate surface receptors. In this study, we demonstrate that interleukin 1 (IL-1) is an inhibitor of endothelial growth in vitro and in vivo. IL-1 arrested growing, cultured endothelial cells in G1 phase; inhibition of proliferation was dose dependent and occurred in parallel with occupancy of endothelial surface IL-1 receptors. In an angiogenesis model, IL-1 could inhibit… CONTINUE READING


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