• Biology, Medicine
  • Published in
    The Journal of biological…
    1990

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

@article{McConkey1990Interleukin1I,
  title={Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.},
  author={David James McConkey and P Hartzell and Sek C Chow and Sten Christian Orrenius and Mikael Jondal},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 6},
  pages={
          3009-11
        }
}
T cell receptor signaling has been implicated in an intrathymic process of cell selection in which potentially harmful autoreactive precursors are deleted before they emigrate to the periphery. Recent work has shown that immature thymocytes undergo apoptosis, or programmed cell death, upon stimulation via the T cell antigen receptor, and it has been suggested that this mechanism may mediate deletion of the self-reactive clones during T cell development. Here we report that the accessory cell… CONTINUE READING

Citations

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Antagonist effect of Interleukin 1 receptor on normal thymopoiesis and thymus toxicity of 5-azacytidine in mouse.

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  • Bruno Lesourd
  • Medicine
  • The Proceedings of the Nutrition Society
  • 1999
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CITES BACKGROUND