Interleukin-1 induces the expression of mu opioid receptors in endothelial cells.

@article{Vidal1998Interleukin1IT,
  title={Interleukin-1 induces the expression of mu opioid receptors in endothelial cells.},
  author={Estela M. Luengos Vidal and Nina A Patel and Gueyshuang Wu and Milan Fiala and Sulie L. Chang},
  journal={Immunopharmacology},
  year={1998},
  volume={38 3},
  pages={261-6}
}
Immunocytokines, such as interleukin-1 (IL-1), have been shown to be involved in the activation and/or induction of a variety of transcription factors which may modulate the expression of genes possessing DNA binding sites on which these transcription factors act. The promoter DNA sequence of the mu opioid receptor gene contains IL-1 response elements such as NF-IL6, and, therefore, the receptor gene may be responsive to IL-1. To investigate the effect of IL-1 on the opioid receptor gene, the… CONTINUE READING

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