Interleukin-1 induces interleukin-6 production in peripheral blood monocytes.

  title={Interleukin-1 induces interleukin-6 production in peripheral blood monocytes.},
  author={Giovanna Tosato and Karen D. Jones},
  volume={75 6},
Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Some of these signals induce IL-6 effectively only in one cell type, and this selectivity of induction may explain selectivity of biologic effects. In the present study, we show that IL-1 beta… CONTINUE READING


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