Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

@article{Nawroth1986Interleukin1I,
  title={Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.},
  author={Peter P Nawroth and Dean A. Handley and Charles T. Esmon and David M. Stern},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 10},
  pages={
          3460-4
        }
}
Previous studies demonstrated that endothelial cells participate actively in both anticoagulant and procoagulant reactions. Although anticoagulant mechanisms predominate on the surface of quiescent endothelial cells, perturbed endothelial cells can promote coagulation through the coordinated induction of procoagulant activity and suppression of anticoagulant mechanisms. Purified recombinant interleukin 1 was infused intravenously into rabbits and coagulant properties of the native aortic… CONTINUE READING

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