Interleukin-1 induces changes in norepinephrine metabolism in the rat brain

@article{Kabiersch1988Interleukin1IC,
  title={Interleukin-1 induces changes in norepinephrine metabolism in the rat brain},
  author={Alexa Kabiersch and Adriana del Rey and Conrad G. Honegger and Hugo Oscar Besedovsky},
  journal={Brain, Behavior, and Immunity},
  year={1988},
  volume={2},
  pages={267-274}
}
Interleukin-1 (IL-1) is a hormone that, apart from playing a key role in immune and inflammatory processes, can also affect mechanisms under brain control. To gain a better understanding of the action of this cytokine on the CNS, its effects on the contents of norepinephrine (NE), dopamine (DA) and serotonin (5-HT), and their main metabolites and precursors, were evaluated in different regions of the forebrain, brain stem, and spinal cord. Following administration of human recombinant IL-1… CONTINUE READING

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