Interleukin-1 genetic association with periodontitis in clinical practice.

  title={Interleukin-1 genetic association with periodontitis in clinical practice.},
  author={Michael J McDevitt and Hui Yun Wang and C Knobelman and Michael G. Newman and Francesco S di Giovine and Judith Timms and Gordon W. Duff and Kenneth S K S Kornman},
  journal={Journal of periodontology},
  volume={71 2},
BACKGROUND Periodontitis is a bacterial disease modified by multiple risk factors. The pro-inflammatory cytokine interleukin- (IL-1) is a key regulator of the host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption. It has been reported that variations in the IL-1 gene cluster on chromosome 2 are associated with increased susceptibility to severe adult periodontitis. METHODS The present study evaluated the association between a… CONTINUE READING
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