Interleukin-1 gene promoter polymorphism is associated with higher liver fibrosis progression rate in Croatian patients with biochemically active chronic hepatitis

@inproceedings{Grgurevic2017Interleukin1GP,
  title={Interleukin-1 gene promoter polymorphism is associated with higher liver fibrosis progression rate in Croatian patients with biochemically active chronic hepatitis},
  author={Ivica Grgurevic and Sanja Kozi{\'c} Dokmanovi{\'c} and Mira {\vS}{\vc}ukane{\'c}-{\vS}poljar and Ivan Kurelac and Zdenko Sonicki and Marijan Kirin and Nikola {\vS}tokovi{\'c} and Snje{\vz}ana Židovec Lepej and A. Chiodo Vince},
  year={2017}
}
Background and aims: Genetic polymorphisms of immune mediators have been associated with differences in the natural course of chronic hepatitis C (CHC). The aim of this study was to analyze the association of IL-1β gene polymorphism with the stage of liver fibrosis (LF), grade of necroinflammatory activity (NIA) and fibrosis progression rate (FPR) in CHC patients. Patients and methods: The study included 50 treatment-naive Croatian CHC patients (36 male and 14 female; age median 37.5 years… CONTINUE READING

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