Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones.

@article{Manetti1994Interleukin1FT,
  title={Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones.},
  author={Roberto Manetti and Vivian Barak and M P Piccinni and Salvatore Sampognaro and Paola Parronchi and Enrico Maggi and Charles A Dinarello and Sergio Romagnani},
  journal={Research in immunology},
  year={1994},
  volume={145 2},
  pages={93-100}
}
The effects exerted by interleukin-1 (IL1) on the growth and differentiation of human Th1 and Th2 cells were examined. Neither IL1 nor the IL1 receptor antagonist (IL1ra) had detectable activity toward the antigen- or anti-CD3 antibody-induced proliferative response of already established type 1 T helper (Th1) or type 2 T helper (Th2) clones. Moreover, neither exogenous IL1 addiction to, nor neutralization of, endogenously produced IL1 in bulk cultures before cloning changed the Th1-like… CONTINUE READING