Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation.

@article{Tsukamoto1991Interleukin1ET,
  title={Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation.},
  author={Tetsurou Tsukamoto and Takefumi Matsui and Hiroyasu Nakata and Masaaki Ito and Toshiki Natazuka and Masaaki Fukase and Tomoyuki Fujita},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 16},
  pages={
          10143-7
        }
}
Both platelet-derived growth factor (PDGF) and interleukin-1 (IL-1) are produced by activated macrophages and are thought to contribute to bone remodeling, but their precise roles remain to be clarified. The interaction between PDGF and IL-1 was, therefore, studied in normal osteoblast-like cells (MC3T3-E1). The expression of alpha- and beta-PDGF receptors on MC3T3-E1 cells was detected by RNA blot analysis and confirmed by immunoblot analysis. PDGF-induced chemotactic as well as mitogenic… CONTINUE READING

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