Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice.

@article{Hom1992Interleukin1ET,
  title={Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice.},
  author={Joanne Hom and Harold Cole and Thomas B Estridge and V. L. Gliszczynski},
  journal={Clinical immunology and immunopathology},
  year={1992},
  volume={62 1 Pt 1},
  pages={56-65}
}
The development of type II collagen-induced arthritis (CIA) in DBA/1 mice is readily accelerated by treatments with interleukin-1 beta (IL-1 beta). In an attempt to further characterize this IL-1 beta-mediated enhancement of CIA, we first examined the effects of IL-1 beta treatments in other "CIA-susceptible" strains and "CIA-resistant" mice. It was observed that treatments with IL-1 beta also enhanced the onset of arthritis in two B10 recombinant CIA-susceptible strains, B10.T (6R) and B10.DA… CONTINUE READING

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