Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen.

@article{Lundqvist1990Interleukin1DT,
  title={Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen.},
  author={Elisabet Nylander Lundqvist and Ove B{\"a}ck},
  journal={Acta dermato-venereologica},
  year={1990},
  volume={70 5},
  pages={391-4}
}
It is generally accepted that ETAF/IL-1 is produced in epidermis by both keratinocytes and Langerhans' cells. We have studied the density and morphology of Ia+ epidermal dendritic cells in mice after systemic or intracutaneous injection of recombinant IL-1 beta. We found that rIL-1 beta decreased the density of Ia+ dendritic cells in the time period 2-7 days after rIL-1 beta administration. However, the remaining dendritic cells were enlarged and more arborized with increased expression of Ia… CONTINUE READING

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