Interleukin-1 contributes to high level IgG production in the murine MRL/lpr lupus model.

@article{Singh1994Interleukin1CT,
  title={Interleukin-1 contributes to high level IgG production in the murine MRL/lpr lupus model.},
  author={Avtar Kaur Singh and Tatiana V Lebedeva},
  journal={Immunological investigations},
  year={1994},
  volume={23 4-5},
  pages={281-92}
}
The autoimmune syndrome in MRL/lpr mice resembles human lupus, both in its serologic and immunopathologic characteristics. The contribution of IL-1 to high-level Ig production in the MRL/lpr model is poorly understood. We investigated the effect of treating B-cell-enriched, or, B plus T cell suspensions derived from either pre-disease or diseased lupus-prone MRL/lpr mice with IL-1 beta or IL-1 receptor antagonist (IL-1Ra). Disparate patterns of IgG production by B cells and B plus T cells… CONTINUE READING

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