Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells.

@article{Durum1982Interleukin1C,
  title={Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells.},
  author={Scott Kenneth Durum and Richard K. Gershon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 15},
  pages={4747-50}
}
Antigen-primed T cells have been shown to require I-region-compatible adherent cells, as well as the priming antigen, to proliferate in vitro. We postulated that the Ia-recognition event is required for the T cell to induce secretion of the monokine interleukin 1 (IL 1) from adherent cells; the conventionally held view is that Ia is directly required for T… CONTINUE READING