Interleukin-1 can inhibit interferon-beta synthesis and its antiviral action: comparison with tumor necrosis factor.

@article{Kohase1988Interleukin1CI,
  title={Interleukin-1 can inhibit interferon-beta synthesis and its antiviral action: comparison with tumor necrosis factor.},
  author={M. Kohase and Y. Zhang and J. Lin and S. Yamazaki and P. B. Sehgal and J. Vil{\vc}ek},
  journal={Journal of interferon research},
  year={1988},
  volume={8 4},
  pages={
          559-70
        }
}
  • M. Kohase, Y. Zhang, +3 authors J. Vilček
  • Published 1988
  • Biology, Medicine
  • Journal of interferon research
  • Earlier studies showed that both tumor necrosis factor (TNF) and interleukin-1 (IL1) can inhibit virus replication in cultured cells. However, in human FS-4 fibroblasts, in which recombinant human TNF protected cells from encephalomyocarditis (EMC) virus infection, recombinant human IL1 alpha and IL1 beta failed to induce antiviral protection. Moreover, both forms of IL1 inhibited the development of the TNF-induced antiviral state. To elucidate the mechanism of this inhibition, we examined the… CONTINUE READING
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