Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.

@article{Tachida2008Interleukin1BU,
  title={Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.},
  author={Yuriko Tachida and Kazuhiro Nakagawa and Takashi K. Saito and Takaomi C Saido and Takashi Honda and Yuko Saito and Shigeo Murayama and Tamao Endo and Gaku Sakaguchi and Akira Kato and Shinobu Kitazume and Yasuhiro Hashimoto},
  journal={Journal of neurochemistry},
  year={2008},
  volume={104 5},
  pages={1387-93}
}
The proinflammatory cytokine interleukin (IL)-1beta is up-regulated in microglial cells surrounding amyloid plaques, leading to the hypothesis that IL-1beta is a risk factor for Alzheimer's disease. However, we unexpectedly found that IL-1beta significantly enhanced alpha-cleavage, indicated by increases in sAPPalpha and C83, but reduced beta-cleavage, indicated by decreases in sAPPbeta and Abeta40/42, in human neuroblastoma SK-N-SH cells. IL-1beta did not significantly alter the mRNA levels of… CONTINUE READING

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