Interleukin-1 beta regulates proenkephalin gene expression in astrocytes cultured from rat cortex.

@article{Negro1992Interleukin1BR,
  title={Interleukin-1 beta regulates proenkephalin gene expression in astrocytes cultured from rat cortex.},
  author={Alessandro Negro and Alessia Tavella and Laura Facci and Lanfranco Callegaro and Stephen D Skaper},
  journal={Glia},
  year={1992},
  volume={6 3},
  pages={206-12}
}
Glial cells execute essential functions in central nervous system (CNS) development and are also believed to play important roles during gliosis in response to trauma or disease. These developmental and pathological states have also been associated with elevated expression of opioid genes. Because levels of the cytokine interleukin-1 beta (IL-1 beta) increase following CNS lesions, we examined the possible influence of IL-1 beta on the expression of opioid genes in astrocytes cultured from rat… CONTINUE READING